Revue Technique Alfa 159 Sw Pdf
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Revue Technique Alfa 159 Sw Pdf
As observed for cannabinoids, terpenoid production increases with light exposure, but decreases with soil fertility (Langenheim, 1994), and this is supported by the glasshouse experience that demonstrates higher yields if plants experience relative nitrogen lack just prior to harvest (Potter, 2004), favouring floral over foliar growth. EO composition is much more genetically than environmentally determined, however (Franz and Novak, 2010), and while cannabis is allogamous and normally requires repeat selective breeding for maintenance of quality, this problem may be practically circumvented by vegetative propagation of high-performance plants under controlled environmental conditions (light, heat and humidity) (Potter, 2009), and such techniques have proven to provide notable consistency to tight tolerances as Good Manufacturing Practice for any pharmaceutical would require (Fischedick et al., 2010).
Government-approved cannabis supplied to patients in national programmes in the Netherlands and Canada is gamma-irradiated to sterilize coliform bacteria, but the safety of this technique for a smoked and inhaled product has never been specifically tested. Gamma-radiation significantly reduced linalool titres in fresh cilantro (Fan and Sokorai, 2002), and myrcene and linalool in orange juice (Fan and Gates, 2001).
Various cannabis component combinations or cannabis extracts should be examined via high throughput pharmacological screening where not previously accomplished. Another goal is the investigation of the biochemical targets of the cannabis terpenoids, along with their mechanisms of action, particularly in the central nervous system. Possible techniques for such research include radio-labelling of select agents in animals with subsequent necropsy. On a molecular level, investigation of terpenoid changes to phytocannabinoid signal transduction and trafficking may prove illuminating. While it is known that terpenoids bind to odorant receptors in the nasal mucosa (Friedrich, 2004) and proximal olfactory structures (Barnea et al., 2004), it would be essential to ascertain if direct effects in limbic or other cerebral structures are operative. Given that farnesyl pyrophosphate is a sesquiterpenoid precursor and the most potent endogenous agonist yet discovered for GPR92 (McHugh et al., 2010), in silico studies attempting to match minor cannabinoids and terpenoids to orphan GPCRs may prove fruitful. Behavioural assays of agents in animal models may also provide clues. Simple combinations of phytocannabinoids and terpenoids may demonstrate synergy as antibiotics if MICs are appreciable lowered (Wagner and Ulrich-Merzenich, 2009). Ultimately, fMRI and single photon emission computed tomography studies in humans, with simultaneous drug reaction questionnaires and psychometric testing employing individual agents and phytocannabinoid-terpenoid pairings via vaporization or oromucosal application, would likely offer safe and effective methods to investigate possible interactions and synergy.
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14 Les caracteristiques techniques 114 Essence Diesel 1750 TBi 2.0 JTDM 2.0 JTDM Moteur 200 ch 136 ch 170 ch Puissance fi scale 12 cv 7 cv 9 cv 9 cv Confi guration 4 cylindres en ligne 4 cylindres en ligne Cylindrée cm Norme écologique Euro 5 Euro 5 Euro 5 Euro 5 Rapport volumétrique 9,5:1 16,5:1 16,5:1 16,5:1 Puissance maxi : kw (ch CEE) à tr/mn Couple maxi : Nm (mkg-ce) à tr/mn Système d injection 2.0 JTDM 170 ch ECO 147 (200) à (136) à (170) à (170) à (32,7) à (35,6) à (36,7) à (36,7) à Injection électronique avec suralimentation par turbocompresseur Injection directe Multijet avec turbocompresseur et échangeur thermique, système de gestion électronique du moteur Bosch EDC 16C39 Carburant essence sans plomb (95 RON) gasoil Transmission Traction avant avant Boîtier de vitesses manuel manuel Nombre de rapports 6 6 Roues Pneumatiques de série 225/50 R17 205/55 R16 205/55 R16 205/55 R ALFA_159SW_101_132.indd /05/11 15:51
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